| Date | Location | Result | |
| Nov 06, 2021 | Cleveland, OH | Rochester 3, Brandeis 1 (25-17,26-24,23-25,25-23) | Box score |
| Nov 05, 2021 | Cleveland, OH | Washington-St. Louis 3, Rochester 0 (25-16,25-7,25-18) | Box score |
| Nov 05, 2021 | Cleveland, OH | NYU 3, Rochester 0 (25-15,25-16,25-8) | Box score |
| Oct 30, 2021 | Pittsford, NY | Buffalo St. 3, Rochester 2 (18-25,25-18,17-25,25-21,15-11) | Box score |
| Oct 30, 2021 | Pittsford, NY | St. John Fisher 3, Rochester 0 (25-15,25-12,25-22) | Box score |
| Oct 21, 2021 | Rochester, NY | Rochester 3, Houghton 0 (25-13,25-13,25-22) | Box score |
| Oct 17, 2021 | Atlanta, GA | Brandeis 3, Rochester 2 (18-25,25-22,15-25,26-24,17-15) | Box score |
| Oct 17, 2021 | Atlanta, GA | Emory 3, Rochester 0 (25-14,25-14,25-10) | Box score |
| Oct 09, 2021 | Selinsgrove, PA | Susquehanna 3, Rochester 0 (25-11,25-22,25-18) | Box score |
| Oct 09, 2021 | Selinsgrove, PA | Stevens 3, Rochester 0 (25-23,25-19,25-15) | Box score |
| Oct 08, 2021 | Selinsgrove, PA | York (PA) 3, Rochester 0 (25-21,25-7,25-22) | Box score |
| Oct 03, 2021 | Waltham, MA | Carnegie Mellon 3, Rochester 0 (25-17,30-28,25-21) | Box score |
| Oct 03, 2021 | Waltham, MA | Case Western Reserve 3, Rochester 0 (25-16,25-13,25-22) | Box score |
| Sep 28, 2021 | Rochester, NY | SUNY Geneseo 3, Rochester 1 (25-18,25-22,21-25,25-22) | Box score |
| Sep 22, 2021 | Henrietta, NY | RIT 3, Rochester 0 (25-15,26-24,25-19) | Box score |
| Sep 19, 2021 | Chicago, IL | NYU 3, Rochester 0 (25-19,25-11,25-5) | Box score |
| Sep 18, 2021 | Chicago, IL | Chicago 3, Rochester 0 (25-12,25-15,25-19) | Box score |
| Sep 18, 2021 | Chicago, IL | Washington-St. Louis 3, Rochester 0 (25-16,25-11,25-22) | Box score |
| Sep 11, 2021 | Brockport, NY | Rochester 3, Thiel 1 (25-23,25-20,19-25,25-16) | Box score |
| Sep 11, 2021 | Brockport, NY | Ithaca 3, Rochester 0 (25-22,25-15,25-13) | Box score |
| Sep 10, 2021 | Brockport, NY | Brockport 3, Rochester 0 (25-22,25-19,25-10) | Box score |
| Sep 04, 2021 | Rochester, NY | Rochester 3, Medaille 0 (25-15,25-15,25-16) | Box score |
| Sep 04, 2021 | Rochester, NY | Rochester 3, SUNY Oneonta 0 (25-14,25-17,25-21) | Box score |
| Sep 03, 2021 | Rochester, NY | Smith 3, Rochester 2 (25-16,22-25,25-19,17-25,15-13) | Box score |
| Sep 03, 2021 | Rochester, NY | Rochester 3, Buffalo St. 0 (25-19,25-17,25-19) | Box score |
| Sep 01, 2021 | Rochester, NY | Rochester 3, Elmira 0 (25-13,25-18,25-13) | Box score |